OUR SERVICES


Supported by Innovation Fund Denmark, we provide research services for evaluation of pre- and probiotic food additives and drug candidates.

We offer preclinical animal models for both early stage screening of formulation and late stage models with high predictive value for design of clinical studies.

Pre- and Probiotics

Pre- and Probiotics

We monitor the changes in the gut resulting from administration of pre- and probiotic food additives and Investigational Medicinal Products (IMPs).

Dysbiosis Models

Dysbiosis Models

We provide preclinical models with intestinal dysbiosis resembling clinical disease in man (Intestinal Bowel Disease) and dysbiosis due to food intolerance.

Technical Platform

Technical Platform

By application of state-of-the-art next-generation sequencing and bioinformatic tool we can identify specific and dynamic changes in the components of the gutbiome with very high resolution.

Regulatory Compliance

Regulatory Compliance

We design our studies with a strict focus on the regulatory requirements to a resulting data package. All studies are SOP-based and QA-controlled and can be designed to meet specific GXP-requirements (GLP, GMP).

Pipetting
PromethION
Minipigs

THE MiniGut CONSORTIUM


The CRO activities are based on many years of collaboration between academia and business partners.

We combine state-of-the-art technological platforms for sequencing and bioinformatic with high-confinement animal colonies in a SOP-controlled research environment.

With 10+ years of experience, we aim to provide data packages designed to support regulatory requirement for the products of the customers.

Insects for fast screening of compounds

In the biotech and pharma industry, early-stage screening of compounds are often done in vitro or in silico where laboratory setting are used to mimic the gastro-intestinal conditions.

We complement such studies with invertebrate animal models, where the intestinal conditions are studied in situ (in the right place) in a physiologically active gut environment. The chosen models has a microbiological intestinal composition that share common characteristics with the human gutbiome.

Resulting data packages are often used for designing further preclinical development.

Minipigs with high translational value

As an omnivorous animal, the minipig share a lot of the gastro-intestinal feature know from the human gut. In this respect, the minipigs are translationally superior to conventional rodent models. Late stage preclinical studies in minipigs may provide data packages with high predictive value for effect and mode-of-action for design of further clinical studies in man.

THE MiniGut RESEARCH TEAM


Christian Kapel

Christian Kapel

Professor, PhD
Principal Investigator

Helene Kringel

Helene Kringel

Head of Research, PhD
Minipig models

Brian Fredensborg

Brian Fredensborg

Assoc. professor, PhD
Insect models

Dennis Sandris Nielsen

Dennis Sandris Nielsen

Professor, PhD
Pre- and Probiotics

Lars Hestbjerg Hansen

Lars Hestbjerg Hansen

Professor, PhD
Sequencing and Bioinformatics

Niels Peter Hansen

Niels Peter Hansen

Stable and Laboratory Coordinator

COLLABORATORS


INTERNATIONAL REVIEWS


This project is exactly what human microbiome research needs to make an easier transfer of knowledge from basic science to application possible.

The project may have a very strong impact on the development of targeted interventions to modulate a dysbiotic gut microbiome.

Timely very important project, with good chances to become a light house project, and with strong interaction between academia and industry.

» A few words
about us «

The MiniGut project will provide better models for gut-microbiome research in a state-of–the-art technological environment. We aim at combining models for fast screening with models of high translational value. We also aim to complement research done previously in other models and in clinical trials by our collaborators.

— Prof. Christian Kapel
MiniGut PI

CONTACT US


Contact Info

Dr. Neergaards Vej 3
2970 Hørsholm, Denmark

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Inquiries

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